This study focused on the bilateral relationship between Nigeria and the United States of America from 1975 to 1979. The study traced the historical development of Nigeria-US relations with emphasis on Mohammed /Obasanjo foreign policy posture towards the US Government.It also examines the impact of Mohammed’s policy of confrontation and its far reaching effects on Nigeria-US relations. Moreso, the study analyses Obasanjo’s policy of partnership especially with the Carter administration and the implication of this partnership on Nigeria-US relations. Furthermore, the study discussed the relationship between Nigeria and US in key areas such as bilateral trade, oil and gas, power generation, rail transport system, road construction, communication, manufacturing and retail loan finance and general free trade zone. It also examined include politics, military and cultural bilateral relations between the two countries. Attention was also given to the domestic factors that shaped US relations with Nigeria and how Nigeria views the changing role of US government on the African continent. Historical method or approach was employed in this study. Both Primary and Secondary sources were used by the researcher. The study established that Nigeria’s external relation with US has been beneficial to the two countries. Again, it established that the relationship between Nigeria and US is a win-win strategy but this is yet to be thoroughly maximized by the Nigerian government given the political, military, technological and economic base of US as the world Superpower in international politics.